A prospective evaluation of point-of-care measurements of maternal glucose for the diagnosis of gestational diabetes mellitus
A prospective evaluation of point-of-care measurements of maternal glucose for the diagnosis of gestational diabetes mellitus
Date
2020-02-01
Authors
O’Malley, E.G.
Reynolds, C.M.E.
O’Kelly, R.
Killalea, A.
Sheehan, S.R.
Turner, M.J.
Journal Title
Journal ISSN
Volume Title
Publisher
Clinical Chemistry
Abstract
Point-of-care (POC) measurement of glucose is currently recommended only for the monitoring of gestational diabetes mellitus (GDM). This prospective observational study evaluated the use of POC measurements of maternal glucose to diagnose GDM in women being screened selectively with a 1-step 75 g oral glucose tolerance test (OGTT).
Description
The strictest preanalytic and analytic international laboratory standards were applied to measure maternal plasma glucose at fasting and at 1 and 2 h post glucose load. The recent International Association of Diabetes and Pregnancy Study Groups diagnostic criteria were used. At the same time, maternal capillary glucose was measured. Because of differences in plasma and capillary glucose measurements, regression analysis of POC capillary glucose results vs laboratory plasma glucose results was conducted. The regression equations for plasma glucose were derived in a derivation cohort (n = 102). These equations were applied in the validation cohort (n = 100). Predicted and actual plasma glucose values were compared.
Keywords
Gestational diabetes mellitus (GMD)
Citation
Eimer G O’Malley, Ciara M E Reynolds, Ruth O’Kelly, Anne Killalea, Sharon R Sheehan, Michael J Turner, A Prospective Evaluation of Point-of-Care Measurements of Maternal Glucose for the Diagnosis of Gestational Diabetes Mellitus, Clinical Chemistry, Volume 66, Issue 2, February 2020, Pages 316–323, https://doi.org/10.1093/clinchem/hvz005